Human Metabotropic Glutamate Receptor 8 (GRM8) activation kit by CRISPRa

CAT#: GA101973

GRM8 CRISPRa kit - CRISPR gene activation of human glutamate metabotropic receptor 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GRM8
• Locus ID: 2918
• Kit Components:

  GA101973G1, Metabotropic Glutamate Receptor 8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101973G2, Metabotropic Glutamate Receptor 8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101973G3, Metabotropic Glutamate Receptor 8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000845, NM_001127323, NM_001127326, NR_028041
• Synonyms: GLUR8; GPRC1H; mGlu8; MGLUR8
• Summary: 'L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]'