Human GSK3 beta (GSK3B) activation kit by CRISPRa

CAT#: GA101983

GSK3B CRISPRa kit - CRISPR gene activation of human glycogen synthase kinase 3 beta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GSK3B
• Locus ID: 2932
• Kit Components:

  GA101983G1, GSK3 beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101983G2, GSK3 beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101983G3, GSK3 beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001146156, NM_002093, NM_001354596
• Synonyms: glycogen synthase kinase-3 beta; glycogen synthase kinase 3 beta; GSK3beta isoform
• Summary: 'The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]'