Human GUCY1B1 activation kit by CRISPRa

CAT#: GA102024

GUCY1B1 CRISPRa kit - CRISPR gene activation of human guanylate cyclase 1 soluble subunit beta 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GUCY1B1
• Locus ID: 2983
• Kit Components:

  GA102024G1, GUCY1B1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102024G2, GUCY1B1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102024G3, GUCY1B1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000857, NM_001291951, NM_001291952, NM_001291953, NM_001291954, NM_001291955
• Synonyms: GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3; GUCY1B1
• Summary: 'This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]'