Human Orexin (HCRT) activation kit by CRISPRa

CAT#: GA102084

HCRT CRISPRa kit - CRISPR gene activation of human hypocretin neuropeptide precursor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HCRT
• Locus ID: 3060
• Kit Components:

  GA102084G1, Orexin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102084G2, Orexin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102084G3, Orexin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001524
• Synonyms: NRCLP1; OX; PPOX
• Summary: 'This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]'