Human MR1 activation kit by CRISPRa

CAT#: GA102141

MR1 CRISPRa kit - CRISPR gene activation of human major histocompatibility complex, class I-related

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MR1
• Locus ID: 3140
• Kit Components:

  GA102141G1, MR1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA102141G2, MR1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA102141G3, MR1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001194999, NM_001195000, NM_001195035, NM_001310213, NM_001531
• Synonyms: HLALS
• Summary: MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]