Human HMGB2 activation kit by CRISPRa

CAT#: GA102146

HMGB2 CRISPRa kit - CRISPR gene activation of human high mobility group box 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HMGB2
• Locus ID: 3148
• Kit Components:

  GA102146G1, HMGB2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102146G2, HMGB2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102146G3, HMGB2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130688, NM_001130689, NM_002129
• Synonyms: HMG2
• Summary: 'This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]'