Human HNRNPD activation kit by CRISPRa

CAT#: GA102173

HNRNPD CRISPRa kit - CRISPR gene activation of human heterogeneous nuclear ribonucleoprotein D

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HNRNPD
• Locus ID: 3184
• Kit Components:

  GA102173G1, HNRNPD gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102173G2, HNRNPD gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102173G3, HNRNPD gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001003810, NM_002138, NM_031369, NM_031370
• Synonyms: AUF1; AUF1A; hnRNPD0; HNRPD; P37
• Summary: 'This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]'