Human HPD activation kit by CRISPRa

CAT#: GA102224

HPD CRISPRa kit - CRISPR gene activation of human 4-hydroxyphenylpyruvate dioxygenase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HPD
• Locus ID: 3242
• Kit Components:

  GA102224G1, HPD gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102224G2, HPD gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102224G3, HPD gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001171993, NM_002150
• Synonyms: 4-HPPD; 4HPPD; GLOD3; HPPDASE; PPD
• Summary: 'The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]'