Human IGFBP1 activation kit by CRISPRa

CAT#: GA102353

IGFBP1 CRISPRa kit - CRISPR gene activation of human insulin like growth factor binding protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IGFBP1
• Locus ID: 3484
• Kit Components:

  GA102353G1, IGFBP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102353G2, IGFBP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102353G3, IGFBP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000596, NM_001013029
• Synonyms: AFBP; hIGFBP-1; IBP1; IGF-BP25; PP12
• Summary: 'This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017]'