Human IL1 alpha (IL1A) activation kit by CRISPRa

CAT#: GA102371

IL1A CRISPRa kit - CRISPR gene activation of human interleukin 1 alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL1A
• Locus ID: 3552
• Kit Components:

  GA102371G1, IL1 alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102371G2, IL1 alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102371G3, IL1 alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000575
• Synonyms: IL-1A; IL1; IL1-ALPHA; IL1F1
• Summary: 'The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]'