Human IL12RB2 activation kit by CRISPRa

CAT#: GA102404

IL12RB2 CRISPRa kit - CRISPR gene activation of human interleukin 12 receptor subunit beta 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL12RB2
• Locus ID: 3595
• Kit Components:

  GA102404G1, IL12RB2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102404G2, IL12RB2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102404G3, IL12RB2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001258214, NM_001258215, NM_001258216, NM_001559, NR_047583, NR_047584, NM_001319233
• Synonyms: RP11-102M16.1
• Summary: 'The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]'