Human CD137 (TNFRSF9) activation kit by CRISPRa

CAT#: GA102411

TNFRSF9 CRISPRa kit - CRISPR gene activation of human TNF receptor superfamily member 9

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TNFRSF9
• Locus ID: 3604
• Kit Components:

  GA102411G1, CD137 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102411G2, CD137 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102411G3, CD137 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001561
• Synonyms: 4-1BB; CD137; CDw137; ILA
• Summary: 'The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]'