Human IMPDH1 activation kit by CRISPRa

CAT#: GA102420

IMPDH1 CRISPRa kit - CRISPR gene activation of human inosine monophosphate dehydrogenase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IMPDH1
• Locus ID: 3614
• Kit Components:

  GA102420G1, IMPDH1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102420G2, IMPDH1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102420G3, IMPDH1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000883, NM_001102605, NM_001142573, NM_001142574, NM_001142575, NM_001142576, NM_001304521, NM_183243
• Synonyms: IMPD; IMPD1; LCA11; RP10; sWSS2608
• Summary: 'The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]'