Human Kv4.3 (KCND3) activation kit by CRISPRa

CAT#: GA102528

KCND3 CRISPRa kit - CRISPR gene activation of human potassium voltage-gated channel subfamily D member 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCND3
• Locus ID: 3752
• Kit Components:

  GA102528G1, Kv4.3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102528G2, Kv4.3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102528G3, Kv4.3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004980, NM_172198
• Synonyms: KCND3L; KCND3S; KSHIVB; KV4.3; SCA19; SCA22
• Summary: 'Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]'