Human KCNH1 activation kit by CRISPRa

CAT#: GA102532

KCNH1 CRISPRa kit - CRISPR gene activation of human potassium voltage-gated channel subfamily H member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNH1
• Locus ID: 3756
• Kit Components:

  GA102532G1, KCNH1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102532G2, KCNH1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102532G3, KCNH1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002238, NM_172362
• Synonyms: EAG; EAG1; h-eag; hEAG1; Kv10.1; TMBTS; ZLS1
• Summary: 'Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]'