Human Kir4.1 (KCNJ10) activation kit by CRISPRa

CAT#: GA102542

KCNJ10 CRISPRa kit - CRISPR gene activation of human potassium voltage-gated channel subfamily J member 10

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNJ10
• Locus ID: 3766
• Kit Components:

  GA102542G1, Kir4.1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102542G2, Kir4.1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102542G3, Kir4.1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002241
• Synonyms: BIRK-10; KCNJ13-PEN; KIR1.2; KIR4.1; SESAME
• Summary: 'This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]'