Human KCNQ2 activation kit by CRISPRa

CAT#: GA102559

KCNQ2 CRISPRa kit - CRISPR gene activation of human potassium voltage-gated channel subfamily Q member 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNQ2
• Locus ID: 3785
• Kit Components:

  GA102559G1, KCNQ2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102559G2, KCNQ2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102559G3, KCNQ2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004518, NM_172106, NM_172107, NM_172108, NM_172109
• Synonyms: BFNC; BFNS1; EBN; EBN1; EIEE7; ENB1; HNSPC; KCNA11; KV7.2; KVEBN1
• Summary: 'The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'