Human Lysosomal acid lipase (LIPA) activation kit by CRISPRa

CAT#: GA102702

LIPA CRISPRa kit - CRISPR gene activation of human lipase A, lysosomal acid type

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LIPA
• Locus ID: 3988
• Kit Components:

  GA102702G1, Lysosomal acid lipase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102702G2, Lysosomal acid lipase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102702G3, Lysosomal acid lipase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000235, NM_001127605, NM_001288979, NR_110233
• Synonyms: CESD; LAL
• Summary: 'This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]'