Human LLGL2 activation kit by CRISPRa

CAT#: GA102707

LLGL2 CRISPRa kit - CRISPR gene activation of human LLGL scribble cell polarity complex component 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LLGL2
• Locus ID: 3993
• Kit Components:

  GA102707G1, LLGL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102707G2, LLGL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102707G3, LLGL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001015002, NM_001031803, NM_004524
• Synonyms: HGL; Hugl-2; LGL2
• Summary: 'The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]'