Human MC2 receptor (MC2R) activation kit by CRISPRa

CAT#: GA102835

MC2R CRISPRa kit - CRISPR gene activation of human melanocortin 2 receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MC2R
• Locus ID: 4158
• Kit Components:

  GA102835G1, MC2 receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102835G2, MC2 receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102835G3, MC2 receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000529, NM_001291911
• Synonyms: ACTHR
• Summary: 'MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]'