Human MCM3 activation kit by CRISPRa
CAT#: GA102845
MCM3 CRISPRa kit - CRISPR gene activation of human minichromosome maintenance complex component 3
Find the corresponding CRISPRi Inhibitor Kit
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 3gRNAs, 1 scramble ctrl and 1 enhancer vector |
Symbol | MCM3 |
Locus ID | 4172 |
Kit Components | GA102845G1, MCM3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102845G2, MCM3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102845G3, MCM3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001270472, NM_002388, NR_158966, NM_001366369, NM_001366371, NM_001366375, NR_158964, NM_001366370, NM_001366372, NM_001366373, NM_001366374, NR_158963, NR_158965 |
Synonyms | HCC5; P1-MCM3; P1.h; RLFB |
Summary | 'The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]' |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN400208 | MCM3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
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