Human MEF2C activation kit by CRISPRa

CAT#: GA102866

MEF2C CRISPRa kit - CRISPR gene activation of human myocyte enhancer factor 2C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MEF2C
• Locus ID: 4208
• Kit Components:

  GA102866G1, MEF2C gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102866G2, MEF2C gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102866G3, MEF2C gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001131005, NM_001193347, NM_001193348, NM_001193349, NM_001193350, NM_001308002, NM_002397, NM_001363581, NM_001364332, NM_001364333, NM_001364335, NM_001364337, NM_001364338, NM_001364339, NM_001364340, NM_001364343, NM_001364344, NM_001364346, NM_001364347, NM_001364349, NM_001364353, NM_001364354, NM_001364355, NM_001364329, NM_001364330, NM_001364331, NM_001364334, NM_001364336, NM_001364341, NM_001364342, NM_001364345, NM_001364348, NM_001364350, NM_001364352, NM_001364356, NM_001364357
• Synonyms: C5DELq14.3; DEL5q14.3
• Summary: 'This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]'