Human MITF activation kit by CRISPRa

CAT#: GA102913

MITF CRISPRa kit - CRISPR gene activation of human melanocyte inducing transcription factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MITF
• Locus ID: 4286
• Kit Components:

  GA102913G1, MITF gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102913G2, MITF gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102913G3, MITF gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000248, NM_001184967, NM_001184968, NM_006722, NM_198158, NM_198159, NM_198177, NM_198178, NM_001354604, NM_001354605, NM_001354606, NM_001354607, NM_001354608
• Synonyms: bHLHe32; CMM8; MI; WS2; WS2A
• Summary: 'The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. [provided by RefSeq, Aug 2017]'