Human Ataxin 3 (ATXN3) activation kit by CRISPRa

CAT#: GA102914

ATXN3 CRISPRa kit - CRISPR gene activation of human ataxin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ATXN3
• Locus ID: 4287
• Kit Components:

  GA102914G1, Ataxin 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102914G2, Ataxin 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102914G3, Ataxin 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001024631, NM_001127696, NM_001127697, NM_001164774, NM_001164775, NM_001164776, NM_001164777, NM_001164778, NM_001164779, NM_001164780, NM_001164781, NM_001164782, NM_004993, NM_030660, NR_028453, NR_028454, NR_028455, NR_028456, NR_028457, NR_028458, NR_028459, NR_028460, NR_028461, NR_028462, NR_028463, NR_028464, NR_028465, NR_028466, NR_028467, NR_028468, NR_028469, NR_028470, NR_031765
• Synonyms: AT3; ATX3; JOS; MJD; MJD1; SCA3
• Summary: 'Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2016]'