Human MMP13 activation kit by CRISPRa

CAT#: GA102942

MMP13 CRISPRa kit - CRISPR gene activation of human matrix metallopeptidase 13

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MMP13
• Locus ID: 4322
• Kit Components:

  GA102942G1, MMP13 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102942G2, MMP13 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102942G3, MMP13 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002427
• Synonyms: CLG3; MANDP1; MDST; MMP-13
• Summary: 'This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]'