Human Mannose Phosphate Isomerase (MPI) activation kit by CRISPRa

CAT#: GA102961

MPI CRISPRa kit - CRISPR gene activation of human mannose phosphate isomerase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MPI
• Locus ID: 4351
• Kit Components:

  GA102961G1, Mannose Phosphate Isomerase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102961G2, Mannose Phosphate Isomerase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102961G3, Mannose Phosphate Isomerase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001289155, NM_001289156, NM_001289157, NM_002435, NM_001330372
• Synonyms: CDG1B; PMI; PMI1
• Summary: 'Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]'