Human Macrophage Scavenger Receptor I (MSR1) activation kit by CRISPRa

CAT#: GA102988

MSR1 CRISPRa kit - CRISPR gene activation of human macrophage scavenger receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MSR1
• Locus ID: 4481
• Kit Components:

  GA102988G1, Macrophage Scavenger Receptor I gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102988G2, Macrophage Scavenger Receptor I gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102988G3, Macrophage Scavenger Receptor I gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002445, NM_138715, NM_138716, NM_001363744
• Synonyms: CD204; phSR1; phSR2; SCARA1; SR-A; SRA
• Summary: 'This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]'