Human n-Myc (MYCN) activation kit by CRISPRa

CAT#: GA103057

MYCN CRISPRa kit - CRISPR gene activation of human MYCN proto-oncogene, bHLH transcription factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MYCN
• Locus ID: 4613
• Kit Components:

  GA103057G1, n-Myc gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103057G2, n-Myc gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103057G3, n-Myc gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001293228, NM_001293231, NM_001293233, NM_005378
• Synonyms: bHLHe37; MODED; N-myc; NMYC; ODED
• Summary: 'This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]'