Human GADD45B activation kit by CRISPRa

CAT#: GA103059

GADD45B CRISPRa kit - CRISPR gene activation of human growth arrest and DNA damage inducible beta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GADD45B
• Locus ID: 4616
• Kit Components:

  GA103059G1, GADD45B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103059G2, GADD45B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103059G3, GADD45B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015675
• Synonyms: GADD45BETA; MYD118
• Summary: 'This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]'