Human NAB2 activation kit by CRISPRa

CAT#: GA103099

NAB2 CRISPRa kit - CRISPR gene activation of human NGFI-A binding protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NAB2
• Locus ID: 4665
• Kit Components:

  GA103099G1, NAB2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103099G2, NAB2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103099G3, NAB2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005967, NM_001330305
• Synonyms: MADER
• Summary: 'This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]'