Human NDUFS1 activation kit by CRISPRa

CAT#: GA103148

NDUFS1 CRISPRa kit - CRISPR gene activation of human NADH:ubiquinone oxidoreductase core subunit S1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NDUFS1
• Locus ID: 4719
• Kit Components:

  GA103148G1, NDUFS1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103148G2, NDUFS1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103148G3, NDUFS1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199981, NM_001199982, NM_001199983, NM_001199984, NM_005006
• Synonyms: CI-75k; CI-75Kd; PRO1304
• Summary: 'The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]'