Human Natriuretic Peptide Receptor A (NPR1) activation kit by CRISPRa

CAT#: GA103258

NPR1 CRISPRa kit - CRISPR gene activation of human natriuretic peptide receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NPR1
• Locus ID: 4881
• Kit Components:

  GA103258G1, Natriuretic Peptide Receptor A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103258G2, Natriuretic Peptide Receptor A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103258G3, Natriuretic Peptide Receptor A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000906
• Synonyms: ANPa; ANPRA; GUC2A; GUCY2A; NPRA
• Summary: 'Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]'