Human Nurr1 (NR4A2) activation kit by CRISPRa

CAT#: GA103295

NR4A2 CRISPRa kit - CRISPR gene activation of human nuclear receptor subfamily 4 group A member 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NR4A2
• Locus ID: 4929
• Kit Components:

  GA103295G1, Nurr1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103295G2, Nurr1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103295G3, Nurr1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006186, NM_173171, NM_173172, NM_173173
• Synonyms: HZF-3; NOT; NURR1; RNR1; TINUR
• Summary: 'This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]'