Human OGDH activation kit by CRISPRa

CAT#: GA103312

OGDH CRISPRa kit - CRISPR gene activation of human oxoglutarate dehydrogenase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OGDH
• Locus ID: 4967
• Kit Components:

  GA103312G1, OGDH gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103312G2, OGDH gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103312G3, OGDH gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001003941, NM_001165036, NM_002541, NM_001363523
• Synonyms: AKGDH; E1k; OGDC
• Summary: 'This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]'