Human P2Y6 (P2RY6) activation kit by CRISPRa

CAT#: GA103360

P2RY6 CRISPRa kit - CRISPR gene activation of human pyrimidinergic receptor P2Y6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: P2RY6
• Locus ID: 5031
• Kit Components:

  GA103360G1, P2Y6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103360G2, P2Y6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103360G3, P2Y6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001277204, NM_001277205, NM_001277206, NM_001277207, NM_001277208, NM_004154, NM_176796, NM_176797, NM_176798
• Synonyms: P2Y6
• Summary: 'The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]'