Human PAK3 activation kit by CRISPRa

CAT#: GA103380

PAK3 CRISPRa kit - CRISPR gene activation of human p21 (RAC1) activated kinase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PAK3
• Locus ID: 5063
• Kit Components:

  GA103380G1, PAK3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103380G2, PAK3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103380G3, PAK3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001128166, NM_001128167, NM_001128168, NM_001128172, NM_001128173, NM_001324325, NM_001324326, NM_001324327, NM_001324328, NM_001324329, NM_001324330, NM_001324331, NM_001324332, NM_001324333, NM_001324334, NM_002578, NR_136740, NR_136741, NR_136742, NR_136743, NR_136744, NR_136745, NR_136746, NR_136747, NR_136748
• Synonyms: ARA; beta-PAK; bPAK; MRX30; MRX47; OPHN3; PAK-3; PAK3beta
• Summary: 'The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017]'