Human PCBD1 activation kit by CRISPRa

CAT#: GA103403

PCBD1 CRISPRa kit - CRISPR gene activation of human pterin-4 alpha-carbinolamine dehydratase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PCBD1
• Locus ID: 5092
• Kit Components:

  GA103403G1, PCBD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103403G2, PCBD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103403G3, PCBD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000281, NM_001001939, NM_001289797, NM_001323004
• Synonyms: DCOH; PCBD; PCD; PHS
• Summary: 'This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]'