Human PDE1C activation kit by CRISPRa

CAT#: GA103434

PDE1C CRISPRa kit - CRISPR gene activation of human phosphodiesterase 1C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDE1C
• Locus ID: 5137
• Kit Components:

  GA103434G1, PDE1C gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103434G2, PDE1C gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103434G3, PDE1C gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001191056, NM_001191057, NM_001191058, NM_001191059, NM_001322055, NM_001322056, NM_001322057, NM_001322058, NM_001322059, NM_005020
• Synonyms: cam-PDE 1C; hCam-3; Hcam3
• Summary: 'This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]'