Human PDE1B activation kit by CRISPRa

CAT#: GA103450

PDE1B CRISPRa kit - CRISPR gene activation of human phosphodiesterase 1B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDE1B
• Locus ID: 5153
• Kit Components:

  GA103450G1, PDE1B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103450G2, PDE1B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103450G3, PDE1B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000924, NM_001165975, NM_001288768, NM_001288769, NM_001315534, NM_001315535
• Synonyms: PDE1B1; PDES1B
• Summary: 'The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]'