Human PDGF AA (PDGFA) activation kit by CRISPRa

CAT#: GA103451

PDGFA CRISPRa kit - CRISPR gene activation of human platelet derived growth factor subunit A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDGFA
• Locus ID: 5154
• Kit Components:

  GA103451G1, PDGF AA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103451G2, PDGF AA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103451G3, PDGF AA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002607, NM_033023
• Synonyms: PDGF-A; PDGF1
• Summary: 'This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]'