Human PDGF Receptor alpha (PDGFRA) activation kit by CRISPRa

CAT#: GA103453

PDGFRA CRISPRa kit - CRISPR gene activation of human platelet derived growth factor receptor alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDGFRA
• Locus ID: 5156
• Kit Components:

  GA103453G1, PDGF Receptor alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103453G2, PDGF Receptor alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103453G3, PDGF Receptor alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006206, NM_001347827, NM_001347828, NM_001347829, NM_001347830
• Synonyms: CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
• Summary: 'This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]'