Human PDGF Receptor beta (PDGFRB) activation kit by CRISPRa

CAT#: GA103456

PDGFRB CRISPRa kit - CRISPR gene activation of human platelet derived growth factor receptor beta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDGFRB
• Locus ID: 5159
• Kit Components:

  GA103456G1, PDGF Receptor beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103456G2, PDGF Receptor beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103456G3, PDGF Receptor beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002609, NM_001355016, NM_001355017, NR_149150
• Synonyms: CD140B; IBGC4; IMF1; JTK12; PDGFR; PDGFR-1; PDGFR1
• Summary: 'The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]'