Human PGAM2 activation kit by CRISPRa

CAT#: GA103510

PGAM2 CRISPRa kit - CRISPR gene activation of human phosphoglycerate mutase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PGAM2
• Locus ID: 5224
• Kit Components:

  GA103510G1, PGAM2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103510G2, PGAM2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103510G3, PGAM2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000290
• Synonyms: GSD10; PGAM-M; PGAMM
• Summary: 'Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq, Sep 2009]'