Human Progesterone Receptor (PGR) activation kit by CRISPRa

CAT#: GA103520

PGR CRISPRa kit - CRISPR gene activation of human progesterone receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PGR
• Locus ID: 5241
• Kit Components:

  GA103520G1, PGR gRNA vector 1 in pCas-Guide-CRISPRa

  GA103520G2, PGR gRNA vector 2 in pCas-Guide-CRISPRa

  GA103520G3, PGR gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000926, NM_001202474, NM_001271161, NM_001271162, NR_073141, NR_073142, NR_073143
• Synonyms: NR3C3; PR
• Summary: This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]