Human SERPINB6 activation kit by CRISPRa

CAT#: GA103538

SERPINB6 CRISPRa kit - CRISPR gene activation of human serpin family B member 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SERPINB6
• Locus ID: 5269
• Kit Components:

  GA103538G1, SERPINB6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103538G2, SERPINB6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103538G3, SERPINB6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001195291, NM_001271822, NM_001271823, NM_001271824, NM_001271825, NM_001297699, NM_001297700, NM_004568
• Synonyms: CAP; DFNB91; MSTP057; PI-6; PI6; PTI; SPI3
• Summary: 'The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]'