Human PI 3 Kinase Class 2A (PIK3C2A) activation kit by CRISPRa

CAT#: GA103551

PIK3C2A CRISPRa kit - CRISPR gene activation of human phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PIK3C2A
• Locus ID: 5286
• Kit Components:

  GA103551G1, PI 3 Kinase Class 2A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103551G2, PI 3 Kinase Class 2A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103551G3, PI 3 Kinase Class 2A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002645, NM_001321378, NM_001321380
• Synonyms: CPK; PI3-K-C2(ALPHA); PI3-K-C2A
• Summary: 'The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]'