Human Cytochrome P450 Reductase (POR) activation kit by CRISPRa
CAT#: GA103670
POR CRISPRa kit - CRISPR gene activation of human cytochrome p450 oxidoreductase
Find the corresponding CRISPRi Inhibitor Kit
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 3gRNAs, 1 scramble ctrl and 1 enhancer vector |
Symbol | POR |
Locus ID | 5447 |
Kit Components | GA103670G1, Cytochrome P450 Reductase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103670G2, Cytochrome P450 Reductase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103670G3, Cytochrome P450 Reductase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_000941, NM_001367562 |
Synonyms | CPR; CYPOR; P450R |
Summary | 'This gene encodes an endoplasmic reticulum membrane oxidoreductase that is essential for multiple metabolic processes, including reactions catalyzed by cytochrome P450 proteins for metabolism of steroid hormones, drugs and xenobiotics. The encoded protein has a flavin adenine dinucleotide (FAD)-binding domain and a flavodoxin-like domain which bind two cofactors, FAD and FMN, that allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene cause a complex set of disorders, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome, that resemble those caused by defects in steroid metabolizing enzymes such as aromatase, 21-hydroxylase, and 17 alpha-hydroxylase. [provided by RefSeq, Aug 2020]' |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN402172 | POR - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
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