Human Protein C (PROC) activation kit by CRISPRa

CAT#: GA103810

PROC CRISPRa kit - CRISPR gene activation of human protein C, inactivator of coagulation factors Va and VIIIa

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PROC
• Locus ID: 5624
• Kit Components:

  GA103810G1, Protein C gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103810G2, Protein C gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103810G3, Protein C gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000312
• Synonyms: APC; PC; PROC1; THPH3; THPH4
• Summary: 'This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]'