Human PRSS2 activation kit by CRISPRa

CAT#: GA103825

PRSS2 CRISPRa kit - CRISPR gene activation of human serine protease 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PRSS2
• Locus ID: 5645
• Kit Components:

  GA103825G1, PRSS2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103825G2, PRSS2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103825G3, PRSS2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001303414, NM_002770, NR_130149
• Synonyms: TRY2; TRY8; TRYP2
• Summary: 'This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]'