Human PTPH1 (PTPN3) activation kit by CRISPRa

CAT#: GA103921

PTPN3 CRISPRa kit - CRISPR gene activation of human protein tyrosine phosphatase non-receptor type 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTPN3
• Locus ID: 5774
• Kit Components:

  GA103921G1, PTPH1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103921G2, PTPH1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103921G3, PTPH1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145368, NM_001145369, NM_001145370, NM_001145371, NM_001145372, NM_002829, NR_026918
• Synonyms: PTP-H1; PTPH1
• Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]'